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Levocetirizine Dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Levocetirizine Dihydrochloride图片
CAS NO:130018-87-0
包装:1 g
市场价:5278元

产品名称
(-)-Cetirizine Dihydrochloride
Xyzal Dihydrochloride
产品介绍
Levocetirizine Dihydrochloride ((R)-Cetirizine dihydrochloride) 是第三代 peripHERal H1-receptor 拮抗剂。Levocetirizine dihydrochloride 是一种抗组胺剂,是 Cetirizine 的 R 对映体。Levocetirizine dihydrochloride 对组胺 H1-受体的亲和力高于 (S)-Cetirizine,并且可用于研究变应性鼻炎和慢性特发性荨麻疹。

产品描述

Levocetirizine Dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria.

体内活性

Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) treatment shows that the Cmax, AUC0-t, AUC0-∞ and t1/2 are 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively in Sprague-Dawley rats[1].

Cas No.

130018-87-0

分子式

C21H27Cl3N2O3

分子量

461.81

别名

(-)-Cetirizine Dihydrochloride;Xyzal Dihydrochloride

储存和溶解度

DMSO:90mg/mL (194.9mM),Need ultrasonic
H2O:90mg/mL (194.9mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years