Lofepramine 是一种有效的三环抗抑郁药，广泛地代谢为 Desipramine。它能够抑制摄取促进去甲肾上腺素能神经传递，以及抑制神经元摄取 5-羟色胺和色氨酸吡咯酶，增强 5-羟色胺能神经传递，进而发挥其抗抑郁作用。它还具有显著的抗焦虑效果。

Lofepramine is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, respectively, with weak antagonism of serotonin, histamine and muscarinic receptors.

23047-25-8

C26H27ClN2O

418.96

Lopramine;Leo 640;洛非帕明;Amplit;Gamanil

DMSO:48 mg/mL (114.57 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years