RS 8359 是单胺氧化酶 A (MAO-A) 的可逆抑制剂,对 A:B 酶类型的特异性比约为 2200。 RS 8359 具有抗抑郁活性。
产品描述
RS 8359 is a reversible inhibitor of monoamine oxidase A (MAO-A) with a selectivity ratio of about 2200 for the A:B enzyme types. RS 8359 has antidepressant activity.
体内活性
RS 8359 shows relatively little effect upon blood pressure when administered together with tyramine, thus effectively eliminating the 'cheese' effect which has contributed to the limited clinical use of the classical monoamine oxidase inhibitors. RS 8359 shows little affinity for the common central nervous system receptors and little anticholinergic effect[1].
Cas No.
105365-76-2
分子式
C14H12N4O
分子量
252.27
储存和溶解度
DMSO:48 mg/mL (190.27 mM),ultrasonic and warming and heat to 80°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years