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Urolithin C
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Urolithin C图片
CAS NO:165393-06-6
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议

产品介绍
Urolithin C属于多酚类,是鞣花酸的肠道微生物代谢产物,具有胰岛素分泌的葡萄糖依赖性激活活性。Urolithin C是 L 型Ca2+通道开放剂,可增强Ca2+的流入。它通过线粒体介导的途径诱导细胞凋亡,并刺激活性氧的形成。

产品描述

Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.

体外活性

Urolithin C is a glucose-dependent activator of insulin secretion acting by facilitating L-type Ca2+ channel opening and Ca2+ influx into pancreatic β-cells.Urolithin C enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation as shown by higher phosphorylation levels in INS-1 β-cells[2]. Urolithin C stimulates reactive oxygen species (ROS) formation[2].

体内活性

In male Wistar rat, the half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V1/F) is 0.831 L/kg and the steady-state volume of distribution (Vss/F) is 55.6 L/kg after the intraperitoneal administration of Urolithin C (10 mg/kg)[3].

Cas No.

165393-06-6

分子式

C13H8O5

分子量

244.202

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years