BD-AcAc 2 通过喂食可以提高 3.5 mm 的平均血酮体，并降低动物的血浆葡萄糖、胰岛素和瘦素。

BD-AcAc 2 (Ketone Ester), added in diet, could elevate mean blood ketone bodies of 3.5 mm and lowered plasma glucose, insulin, and leptin in animals.

BD-AcAc(2) would delay CNS-OT seizures in rats breathing hyperbaric oxygen (HBO(2)). Adult male rats (n = 60) were implanted with radiotelemetry units to measure electroencephalogram (EEG). One week postsurgery, rats were administered a single oral dose of BD-AcAc(2), 1,3-butanediol (BD), or water 30 min before being placed into a hyperbaric chamber and pressurized to 5 atmospheres absolute (ATA) O2 [1]. Beginning at a presymptomatic age, 2 groups of male 3xTgAD mice were fed a diet containing a physiological enantiomeric precursor of ketone bodies (KET) or an isocaloric carbohydrate diet. The results of behavioral tests performed at 4 and 7 months after diet initiation revealed that KET-fed mice exhibited significantly less anxiety in 2 different tests. 3xTgAD mice on the KET diet also exhibited significant, albeit relatively subtle, improvements in performance on learning and memory tests. Immunohistochemical analyses revealed that KET-fed mice exhibited decreased Aβ deposition in the subiculum, CA1, and CA3 regions of the hippocampus, and the amygdala [2].

1208313-97-6

C8H16O4

176.21

Ketone Ester

H2O:30 mg/mL (170.25 mM),ultrasonic and heat to 60°C
DMSO:96 mg/mL (544.80 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years