PK11007 是一种温和的硫醇烷基化剂，具有抗癌活性。它通过两个表面暴露的半胱氨酸的选择性烷基化来稳定p53。它通过增加活性氧水平诱导突变的p53癌细胞死亡。
产品描述
PK11007 is an anti-p53 drug.
体内活性
Targeting mutant p53 with PK11007 is a potential approach for treating p53-mutated breast cancer, including the subgroup with TN disease[1].
Cas No.
874146-69-7
分子式
C15H11ClFN5O3S2
分子量
427.85
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
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