Thujone是一种从西方金钟柏精油中分离出来的单萜，可穿透血脑屏障。它是GABAA受体的可逆调节剂，在抑制GABA诱导的电流时，它的IC50为 21 μM。它诱导ROS依赖性细胞毒性，还诱导细胞凋亡和自噬。它具有抗伤害，抗肿瘤、杀虫和驱虫活性。

Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.

In in-vivo one-trial passive avoidance paradigm show that thujone (1.25mg/kg, i.p.) significantly impaired nicotine-induced enhancement of learning and memory in Wistar rats[1].

546-80-5

C10H16O

152.237

Thujone;(-)-α-侧柏酮;ALPHA-(-)-THUJONE;α-侧柏酮

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years