您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Zinc Protoporphyrin
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Zinc Protoporphyrin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Zinc Protoporphyrin图片
CAS NO:15442-64-5
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
锌原卟啉
ZnPP
Zn(II)-protoporphyrin IX
Zinc Protoporphyrin-9
产品介绍
Zinc Protoporphyrin 是一种具有口服活性的,竞争性血红素加氧酶-1 抑制剂,显著减弱间苯三酚对 H2O2 的保护作用,具有抗癌活性。它用于评估人群铁状态与血红蛋白浓度的组合,也可用作个体孕妇和儿童缺铁的筛查标志物。

产品描述

Zinc Protoporphyrin is an orally active and competitive inhibitor of heme oxygenase-1 (HO-1) and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2, and has anti-cancer activity.

体外活性

Protoporphyrin zinc (Zn(II)-protoporphyrin IX; 5 μM; 72 hours) increased the proportion of late apoptosis and necrotic cells from 10.9% in the control group to 30.4% after 72 hours [3]. Zinc Protoporphyrin (1.25-40 μM; 48 or 72 hours) exerts cystostatic/cytotoxic effects against tumor cells[3]. Zinc Protoporphyrin (2.5, 5 μM; 48 or 72 hours) results in dose- and time-dependent reduction of cells in G1 phase of the cell cycle[3]. Zinc Protoporphyrin (1.25-40 μM; 48 hours) leads to accumulation of cleaved (active) caspase-3[3].

体内活性

Zinc Protoporphyrin exhibits dose-dependent antitumor effects manifested by the retardation of tumor growth[3].

Cas No.

15442-64-5

分子式

C34H31N4O4Zn

分子量

625.04

别名

锌原卟啉;ZnPP;Zn(II)-protoporphyrin IX;Zinc Protoporphyrin-9

储存和溶解度

DMSO:50 mg/mL (79.87 mM),Need ultrasonic
H2O:< 0.1 mg/mL (insoluble)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years