HTHQ 是一种强力的亲脂性酚类抗氧化剂。它通过与活性氧直接反应，清除ROS，从而形成更稳定的自由基，具有很强的抗氧化活性。

HTHQ, a hydroquinone monoalkyl ether, is an effective anti-oxidative agent. HTHQ is a potent anti-lipid-peroxidative compound and its antioxidation activity to be extremely elevated in biological systems, such as that of liver microsomes via the generation of stable free radicals.

HTHQ has an anti-oxidative activity similar to D,L-alpha-tocopherol against lipid peroxidation in linolate micelles initiated by addition of Fe2+. The anti-lipid-peroxidation activity of HTHQ is higher 4.8-fold than that of D,L-alpha-tocopherol against the peroxidation in phosphatidylcholine liposomes initiated by addition of Fe2+. [1] The effects of 0.02% Glu-P-1 or 0.03% MeIQx on the number and area of foci is significantly reduced by 0.125% HTHQ. [2]

Treatment with HTHQ potently inhibits PhIP-induced mammary carcinogenesis in female rats. Compared with DMN-induced hepatic fibrosis animals in the liver tissue, HTHQ reduced mRNA level of PDGF (Platelet-derived growth factor), α-SMA (α-smooth muscle actin) and TGF-β (transforming growth factor-β). In this study, we showed that HTHQ improves against DMN-induced liver fibrosis in male SD rats.

148081-72-5

C15H24O2

236.355

HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone);HX 1171;1-O-hexyl-2,3,5-trimethylhydroquinone

DMSO:43 mg/mL(181.9 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years