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Giredestrant
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Giredestrant图片
CAS NO:1953133-47-5
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
GDC-9545
产品介绍
Giredestrant 是一种口服有效的、选择性的、非甾体的雌激素受体 (ER) 拮抗剂,具有抗肿瘤作用。它可以在 ER 配体结合域内与雌二醇 (Estradiol) 竞争结合并诱导构象变化。

产品描述

Giredestrant potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity. Giredestrant, a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist.

体外活性

The highly potent in vivo efficacy of Giredestrant likely arises due to the particular combination of high binding potency, full suppression of ER signaling, and an improved DMPK profile.Giredestrant (GDC-9545) is a novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes.

Cas No.

1953133-47-5

分子式

C27H31F5N4O

分子量

522.55

别名

GDC-9545

储存和溶解度

DMSO:100mg/mL (191.37 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years