Aminoguanidine hydrochloride 是二胺氧化酶抑制剂，也是一氧化氮合酶抑制剂，可用于糖尿病肾病的研究。

Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.

Aminoguanidine ameliorates neonatal hypoxic-ischemic brain damage and that temporal profiles of NO correlated with the neuroprotective effect of aminoguanidine. Neuroprotection by AG is attributable to suppression of NO produced by iNOS after the end of the hypoxic period, during the reoxygenation phase. The half-life of AG is estimated to be between 6 and 8 h in vivo and approximately 4.4 h in human with normal renal function.AG is also an inhibitor of the formation of advanced glycation end products. Systematically administered advanced glycation end product–modified BSA increases cerebral infarct size in an adult rat, which is attenuated by AG[2].

1937-19-5

CH7ClN4

110.55

Pimagedine;Guanyl hydrazine;氨基胍盐酸盐;Imino semicarbazide;CP-12009-18 tartrate;肼甲酰亚胺酰胺一氯化氢（氨基胍盐酸盐）;Pimagedine hydrochloride;Hydrazinecarboximidamide

Ethanol:<1 mgml
DMSO:21 mg/mL (190 mM)
H2O:20 mg/mL (180.9 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years