YM17E 是一种 ACAT 抑制剂,在体外兔肝微粒体中的 IC50 为 44 nM。
产品描述
YM17E is an inhibitor of ACAT with IC50 of 44 nM in rabbit liver microsomes in vitro.
体外活性
YM17E is potent in inhibiting ACAT activity in the intestine with IC50 of 34 nM[1].
体内活性
YM17E inhibits the production of [14C]cholesteryloleate from [14C]oleoyl CoA in a dose-dependent manner in both liver and intestinal microsomes used as enzyme sources[1]. YM17E (3, 5, 10 mg/kg, i.v.) significantly inhibits hepatic ACAT activities in a dose-dependent manner. YM17E (oral; i.v.) produces a significant increase in 125I-LDL clearance in atherogenic diet-fed rats. YM17E (3, 10, 30 mg/kg; p.o.) decreases total cholesterol, cholesteryl ester, and non-HDL cholesterol in a dose-dependent manner. YM17E (oral) decreases total cholesterol and cholesteryl ester levels in the liver significantly in a dose-dependent manner[2].
Cas No.
124900-72-7
分子式
C40H56N6O2
分子量
652.91
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years