RP 70676 是ACAT抑制剂，抑制大鼠和兔子中 ACAT的IC50分别为 25 和 44 nM。

RP 70676 is a potent ACAT inhibitor(rat and rabbit ACAT with IC50 of 25 and 44 nM ).

RP 70676 is a potent rabbit arterial ACAT inhibitor with IC50 of 40 nM and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues(IC50 : 44 nM). Murine macrophages the compound has an IC50 of 540 nM in whole cell P388D.

In NZW rabbits,RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels.

136609-26-2

C25H28N4S

416.58

DMSO:125 mg/mL (300.06 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years