CU-CPT9b 是 toll 样受体 8 (TLR8) 的拮抗剂，Kd 为 21 nM。它抑制由 TLR8 激动剂 R-848 在过表达 TLR8 的 HEK-Blue 细胞中诱导的 NF-?B 活化，IC5??0 值为 0.7 nM。

CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM.

2162962-69-6

C16H13NO2

251.285

TLR8-specific antagonist 1;CU-CPT-9b

DMSO:100 mg/mL (397.96 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years