CU-115 是 TLR8 的特异性拮抗剂，对 TLR8 和 TLR7 的 IC50 分别为 1.04 μM 和 >50 μM。

CU-115 is a selective antagonist of TLR8 with IC50s of 1.04 μM and >50 μM for TLR8 and TLR7, respectively.

CU-115 (1, 5, and 20 μM) inhibits TLR9 to 10-25% inhibition. CU-115 (5-20 μM) inhibits increases in the activity of type I IFN transcriptional induced by the ssRNA nucleic acid ligands 3p-hpRNA or G3-YSD. CU-115 (5-20 μM) abolishes the TNF-α production activated by R848 (1 μg/ml) and represses the expression of IL-1β in hTHP-1 cells. CU-115 does not modulate the NF-kB inhibition induced by Pam2CSK4, Pam3CSK4, LPS, R848, Poly(I:C), and Flic in HEK-293 TLR1/2, TLR2/6, TLR3, and TLR4 cells[1].

2471982-20-2

C21H11F7INO2

569.21

DMSO:90 mg/mL (158.1mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years