EOAI3402143 是一种去泛素化酶抑制剂,以剂量依赖性抑制 Usp9x/Usp24和Usp5,增加肿瘤细胞凋亡。
产品描述
EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis. EOAI3402143 phenocopies the FAS induction and apoptotic sensitization of Usp5 knockdown and fully blocks melanoma tumor growth.
体外活性
EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice[2]. Usp9x inhibition by EOAI3402143 treatment reduced 3D colony formation in PANC1 and PDX cell lines, induced rapid apoptosis in MIAPACA2 cells, and associated with reduced Mcl-1 and ITCH protein levels[2].
体内活性
EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice[3].
Cas No.
1699750-95-2
分子式
C25H28Cl2N4O3
分子量
503.42
储存和溶解度
H2O:< 0.1 mg/mL (insoluble)
DMSO:75 mg/mL (148.98 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years