Ro 08-2750 is a novel, potent, selective, and reversible non-peptide inhibitor of Nerve growth factor (NGF), binding to the NGF dimer with a KD of ~ 1 μM. It inhibits NGF binding to p75NTR selectively over TRKA. Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM. NGF has potential effects on matrix turnover activity and influences the catabolic/anabolic balance of IVD cells in an adverse way that may potentiate IVD degeneration. Anti-NGF treatment might be beneficial to ameliorate progressive tissue breakdown in IVD degeneration and may lead to pain relief.

纯度：≥98%

CAS：37854-59-4