Ro 90-7501 is an amyloid β42 fibril assembly inhibitor (EC50: 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. Ro 90-7501 also inhibits PP5 in a TPR-dependent manner. RO 90-7501 selectively enhances TLR3 and RLR ligand-induced IFN-β gene expression and antiviral response.

Ro 90-7501 inhibits the phosphorylation of ATM and its downstream proteins, such as H2AX, Chk1, and Chk2, after irradiation. Ro 90-7501 significantly enhances radiosensitivity compared with control HeLa and ME-180 cells and it also significantly increases apoptosis and impaired cell cycle after irradiation. RO 90-7501, itself affects neither IFN-β nor NFκB promoter activity, but significantly enhances poly I:C-induced IFN-β promoter activation and inhibits the activation of NFκB in a dose-dependent manner. Treatment of cells with RO 90-7501 significantly enhances the antiviral activity of poly I:C [1][2].

Ro 90-7501 (5 μg/g; intraperitoneal injection; daily; for 21 days; female BALB/c nude mice) treatment significantly delays tumor growth. It also obviously reduces tumor volume[1].

293762-45-5

C20H16N6

340.38

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years