SIRT-IN-2 是一种 SIRT1/2/3 有效抑制剂，IC50 分别为 4、1和 7 μM。

SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).

SIRT-IN-2 is one of the most potent truncated pan SIRT1/ 2/3 inhibitor(IC50 values are 4, 4, 7 μM, respectively). SIRT-IN-2 binds identically in the catalytic active site (RMS=0.29 ?), occupying the nicotinamide C-pocket and acetyl lysine substrate channel.

1431411-66-3

C15H21N5O3S2

383.49

DMSO:62.5 mg/mL (151.24 mM,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years