OSS_128167 是一种选择性沉默调节蛋白 6 (SIRT6) 抑制剂，对SIRT6，SIRT1 和 SIRT2 的IC50分别为 89 μM，1578 μM 和 751 μM。它具有抗HBV、抗癌、抗炎和抗病毒活性，可抑制HBV的转录和复制。

OSS_128167 is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).

OSS-128167 increases H3K9 acetylation and GLUT-1 expression, and proves to be a selective compounds toward SIRT6.

In supernatants from cells, which are incubated in OSS_128167 (100 μM) for 18 hours,TNF-a levels are measured .

BxPC3 cells are stimulated with 100 μM OSS-128167 incubating 0, 2, 6, 18, 24 hours.

887686-02-4

C19H14N2O6

366.329

SIRT6-IN-1

DMSO:68 mg/mL (185.6 mM)
H2O:<1 mgml
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years