MC3482是一种特异性Sirtuin5 (SIRT5) 抑制剂。

MC3482 is a specific inhibitor of sirtuin5 (SIRT5).

MC3482 inhibits sirtuin5.50 μM MC3482 inhibits SIRT5 desuccinylating activity without affecting SIRT5 intracellular expression levels. Autophagy and mitophagy increase in SIRT5-silenced cells and in WT cells treated with MC3482 and decrease in SIRT5-overexpressing cells[1].

T11962

C33H38N4O8

618.68

DMSO:117mg/mL (189.1mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years