RK-9123016是一种SIRT2抑制剂。RK-9123016增加真核翻译起始因子5A（eIF5A）（SIRT2的生理底物）的乙酰化水平，降低人乳腺癌细胞的细胞活力，同时降低c-Myc表达。

RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression.

RK-9123016 inhibited the enzymatic activity of SIRT2 with an IC50 value of 0.18 μM but not other human sirtuin members including SIRT1 and SIRT3 at 100 μM in vitro electrophoretic mobility shift assay. RK-9123016 inhibited the SIRT2 activity in MCF-7 cells by concentration dependent manner (0-30 μM).

955900-27-3

C16H18N6O3S

374.42

RK9123016

DMSO:soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years