Naringenin是葡萄柚中主要的黄烷酮，可作为抗氧化剂、自由基清除剂、抗炎剂、碳水化合物代谢促进剂、免疫系统调节剂。

Naringenin is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate metabolism promoter, immunity system modulater. This substance has also been shown to repair DNA.

在血糖正常的和非胰岛素依赖型糖尿病大鼠模型中,灌胃50 mg/kg Naringenin导致血浆葡萄糖明显下降.

在葡萄柚汁中发现的Naringenin被证明对人类细胞色素P450同种型CYP1A2具有抑制作用,其可以以不利方式改变几种常见试剂在人类(或直系同源)宿主中的药代动力学,甚至导致其他无害的物质具有致癌性。

Naringenin is dissolved in DMSO and diluted in cell culture medium. The cells are rinsed with PBS and grown in a medium containing various concentrations of naringenin (50, 100, 150, 200, 250, 300 μM). The solvent DMSO treated cells are served as control. After 24 hrs of treatment, the medium is removed and replaced by another medium containing MTT. Cell viability is measured using the MTT assay[1].

480-41-1

C15H12O5

272.256

柚皮素;Naringetol;Salipurol;NSC 34875;NSC 11855;S-Dihydrogenistein;Pelargidanon

H2O:<1 mgml
Ethanol:5 mg/mL (18.36 mM)
DMSO:50 mg/mL (183.6 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years