Oleoylethanolamide 是一种PPAR-α 的高亲和力内源性激动剂，可用于肥胖和动脉硬化的相关研究。

Oleoylethanolamide is a high affinity endogenous agonist of PPAR-α.

In vitro studies showed that OEA inhibited transforming growth factor β1-stimulated HSCs activation through suppressing Smad2/3 phosphorylation, α-SMA expression and myofibroblast transformation.

Treatment with OEA (5 mg/kg/day, intraperitoneal injection, i.p.) significantly attenuated the progress of liver fibrosis in both two experimental animal models by blocking the activation of hepatic stellate cells (HSCs).?Gene expression analysis of hepatic tissues indicated that OEA inhibited the expression of α-smooth muscle action (α-SMA) and collagen matrix, fibrosis markers, and genes involved in inflammation and extracellular matrix remodeling.

111-58-0

C20H39NO2

325.53

Oleamide MEA;Oleic acid monoethanolamide;油酰单乙醇胺;N-Oleoylethanolamide

DMSO:19.83 mg/mL (60.92 mM),Need ultrasonic
H2O:< 0.1 mg/mL (insoluble)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years