您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > NMS-P118
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
NMS-P118
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NMS-P118图片
CAS NO:1262417-51-5
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
NMS-P118是可口服的高选择性PARP-1抑制剂,用于癌症治疗,在HeLa细胞中的IC50值为0.04 μM。

产品描述

NMS-P118 is a potent, selective and orally available Inhibitor of PARP-1 for cancer therapy.

体外活性

NMS-P118 proved to be a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles and high efficacy in vivo both as a single agent and in combination with Temozolomide in MDA-MB-436 and Capan-1 xenograft models, respectively. Cocrystal structures of 20by with both PARP-1 and PARP-2 catalytic domain proteins allowed rationalization of the observed selectivity.

Cas No.

1262417-51-5

分子式

C20H24F3N3O2

分子量

395.426

储存和溶解度

DMSO:16 mg/mL (40.46 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years