JAK/HDAC-IN-1 是JAK2/HDAC双重抑制剂，对 JAK2 和 HDAC 的IC50值分别为 4 和 2 nM。它在部分血液学细胞系中，具有抗增殖和促凋亡作用。

JAK/HDAC-IN-1 is an effective JAK2/HDAC dual inhibitor (IC50s: 4 and 2 nM for JAK2 and HDAC). It also shows antiproliferative and proapoptotic activities in several hematological cell lines.

JAK/HDAC-IN-1 shows IC50s of 4.8, 7.4, and 49 nM for JAK1, JAK3, and TYK2, and 14, 120, 2470 nM for HDAC2, HDAC6 and HDAC8, respectively.

2284621-75-4

C19H21Cl2N7O2

450.32

DMSO:20.83 mg/mL (46.26 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years