Bufexamac 是 HDAC6 和 HDAC10 的抑制剂,也是一种COX抑制剂,用于释放 IFN-α,具有抗炎、镇痛和解热作用。
产品描述
Bufexamac is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.
体外活性
Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Treatment of peripheral blood mononuclear cells with bufexamac inhibits the secretion of IFN-α. [1] Bufexamac is a frequent and relevant contact sensitizer. Bufexamac is a non-steroidal anti-inflammatory drug. [2]
Cas No.
2438-72-4
分子式
C12H17NO3
分子量
223.27
别名
Bufexamic acid;丁苯羟酸
储存和溶解度
DMSO:42 mg/mL (188.1 mM)
Ethanol:3 mg/mL (13.43 mM)
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years