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WT-161
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
WT-161图片
CAS NO:1206731-57-8
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
WT-161是一种HDAC6选择性有效抑制剂,IC50值为0.40 nM。

产品描述

WT161 is a potent and selective inhibitor of HDAC6 (IC50:0.40 nM).

体外活性

Treatment of anti-multiple myeloma (MM) cell lines with WT161 triggers the accumulation of acetylated tubulin and cell death in MM cell lines more potently than tubacin. Additionally, WT161 in combination with BTZ induces synergistic cytotoxicity and overcomes BTZ resistance in vitro[1].

体内活性

WT161 significantly inhibits in vivo MCF7 cell growth, associated with downregulation of ERα, in a murine xenograft model[2].

动物实验

Female NCr nu/nu mice were subcutaneously (sc) implanted with 17?-estradiol-sustained release pellets (0.18 mg, 60 day release time). Mice were inoculated sc with 5 × 10^6 MCF-7 cells suspended in 30% Matrigel. After 1 month of growth, mice with measurable tumors (>50 mm^3) were assigned into cohorts receiving intraperitoneal WT161 daily (80 mg/kg) or into a control group receiving vehicle alone (10% DMSO, 90% PBS). Caliper measurements of the longest perpendicular tumor diameters were performed every alternate day to estimate the tumor volume, using the formula volume = ? x L x W^2. Animals were sacrificed when tumors reached 2 cm or if the mice appeared moribund. For each animal, relative tumor volume was determined by normalizing data to the baseline tumor volume for that animal at the start of treatment. Statistical significance was determined by 2-way ANOVA analysis[2].

Cas No.

1206731-57-8

分子式

C27H30N4O3

分子量

458.562

储存和溶解度

DMSO:100 mg/mL (218.08 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years