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Tucidinostat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tucidinostat图片
CAS NO:1616493-44-7
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Chidamide
西达本胺
HBI-8000
CS 055
产品介绍

体外活性

Tucidinostat shows potent antitumor activity and inhibits several human-derived tumour cell lines, such as HL-60, U2OS, LNCaP with GI50s of 0.4 ± 0.1, 2.0 ± 0.6, and 4.0 ± 1.2 μM, respectively. In addition, Tucidinostat shows less toxic to normal cells from human fetal kidney (CCC-HEK) and liver (CCCHEL)[1].

体内活性

Tucidinostat (12.5-50 mg/kg, p.o.) dose-dependently reduces tumour size and tumour weight in mice bearing HCT-8 colorectal carcinoma, A549 lung carcinoma, BEL-7402 liver carcinoma, and MCF-7 breast carcinoma, and with no obvious body loss[1].

Cas No.

1616493-44-7

分子式

C22H19FN4O2

分子量

390.418

别名

Chidamide;西达本胺;HBI-8000;CS 055

储存和溶解度

DMSO:50 mg/mL
H2O:Insoluble
Ethanol:1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years