BRD 4354 是 HDAC5 和 HDAC9 的抑制剂,对 HDAC5 和 HDAC9 的 IC50 值分别为 0.85 和 1.88 μM。
产品描述
BRD 4354 is an inhibitor of HDAC5 and HDAC9. For HDAC5 and HDAC9, the IC50s values are 0.85 and 1.88 μM, respectively.
体外活性
BRD 4354 also inhibits HDACs 4, 6, 7, and 8 at higher concentrations (3.88-13.8 μM) but demonstrates less of an inhibitory effect on other class I HDACs 1, 2, and 3 (IC50>40 μM) [1]. BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with BRD4354 having half-maximum inhibitory concentrations (IC50) of 0.85 μM and 1.88 μM, respectively.
Cas No.
315698-07-8
分子式
C21H23ClN4O
分子量
382.89
储存和溶解度
DMSO:10mg/mL (23.01 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years