Nolatrexed dihydrochloride 是一种非竞争性的胸苷酸合酶抑制剂，能够在癌细胞 S 期诱导细胞周期停滞，具有抗癌活性。它与该酶的叶酸辅因子结合位点相互作用，对人胸苷酸合酶的Ki值为 11 nM。

Nolatrexed Dihydrochloride is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.

152946-68-4

C14H14Cl2N4OS

357.25

AG 337;盐酸诺拉曲塞;Thymitaq

DMSO:>10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years