Quarfloxin是一种氟喹诺酮衍生物，具有抗肿瘤活性，可靶向抑制RNA pol I的活性，在神经母细胞瘤细胞中的 IC50 值在纳摩尔范围内。它破坏核糖体 DNA 模板中核仁蛋白和 G-四链体 DNA 结构之间的相互作用。

Quarfloxin is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA template.

Quarfloxin effectively inhibits the growth of neuroblastoma cells in vitro. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines[1].

865311-47-3

C35H33FN6O3

604.67

CX-3543

DMSO:55 mg/ml (90.96 mM)
H2O:1 mg/mL (1.65 mM),ultrasonic and adjust pH to 5 with 0.1 M HCL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years