RAD51 Inhibitor B02 是一种人RAD51的抑制剂，IC50值为27.4 μM。

RAD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM.

RAD51 Inhibitor B02 specifically inhibits human RAD51 (IC50=27.4 μM), but not its E. coli homologue RecA (IC50>250 μM).The combination of B02 with cisplatin has the strongest killing effect on the human breast cancer cells MDA-MB-231.

B02 significantly enhances the therapeutic effect of cisplatin on tumor cells in vivo. B02 is tolerated by mice at doses up to 50 mg/kg without obvious body weight loss. No inhibition of tumor growth is observed on mice solely treated by B02; whereas mice treated with 4 mg/kg cisplatin show a 33% inhibition of tumor growth. Finally, mice treated with 50 mg/kg B02 and 4 mg/kg cisplatin shows a 66% inhibition of tumor growth[2].

1290541-46-6

C22H17N3O

339.39

B02

DMSO:33.9 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years