PI3065 是一种有效的PI3K p110δ抑制剂(IC50=5 nM;Ki=1.5 nM)。它对 p110α,p110β,p110γ 的作用较弱,IC50分别为 910,600,>10000 nM。
产品描述
PI-3065 is a novel potent and selective PI3K p110δ inhibitor.
体外活性
PI-3065 shows no inhibition on the growth of 4T1 cells, which do not expressing detectable levels of p110δ. [1]
细胞实验
Proliferation of 4T1 cells is assayed following a 4-h treatment with the indicated p110δ inhibitors, then washing and MTS staining are carried out after 48 h culture. (Only for Reference)
Cas No.
955977-50-1
分子式
C27H31FN6OS
分子量
506.64
别名
PI3065
储存和溶解度
DMSO:10.1 mg/mL (20 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years