BAY-8400是一种具有口服活性、有效和选择性 DNA 依赖蛋白激酶 (DNA-PK) 抑制剂(IC50=81 nM)，与靶向α疗法联合使用显示协同疗效。BAY-8400 可用于癌症研究。

BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy in combination with targeted alpha therapies. BAY-8400 can be used for the research of cancer [1].

BAY-8400 (150 mg/kg; p.o.) increases the antitumor efficacy that even improved tumor-induced body weight loss. BAY-8400 shows useful aqueous solubility and oral bioavailability across species [1].

T9498

DMSO:60 mg/mL (152.52 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years