Intoplicine is an inhibitor of DNA topoisomerase I and II.

Intoplicine is the most active analogue evaluated in the 7H-benzo[e]-pyrido-[4,3-b]-indole series of antineoplastic compounds. Activity of Intoplicine against human tumor colony-forming units in vitro. Intoplicine shows its activity through inhibition of DNA topoisomerase I and II[1]. Intoplicine is found to unwind DNA and to inhibit purified calf thymus topoisomerase II via stabilization of the ternary cleavable complex[2].

125974-72-3

C21H24N4O

348.44

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years