Bisantrene 是一种具有抗肿瘤活性的蒽基双腙，可靶向作用于真核生物的II型拓扑异构酶。它插入并破坏 DNA 的构型，导致 DNA 单链断裂、DNA-蛋白质交联和 DNA 复制的抑制。

Bisantrene is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity.

78186-34-2

C22H22N8

398.474

CL216942;比生群

DMSO:1 mg/mL (2.51 mM),ultrasonic and warming and heat to 80°C
H2O:0.1 mg/mL (0.25 mM),ultrasonic and warming and heat to 50°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years