Coralyne chloride 是一种具有强抗癌活性的原小檗碱化合物。它可用于制备 Coralyne 衍生物，是一种基于荧光 DNA 的分子整流剂，通过位点特异性插入构建成 DNA 双链体。它可作为一种拓扑异构酶 I 毒性分子，诱导拓扑异构酶 I 介导 DNA 裂解。

Coralyne chloride is a molecular rectifier based on fluorescent DNA, which is constructed into DNA double-stranded bodies by site-specific insertion.

There is synergism between Coralyne and Paclitaxel on proliferation and migration of breast cancer cell lines. This study also showed that combinational drug treatment decreased the expression of ki-67 and there was an increase in pro apoptotic factor Bax with decreased in expression of anti-apoptotic factor Bcl-2 in breast cancer cell lines with negligible effect on normal breast cell line[2].

38989-38-7

C22H22ClNO4

399.87

DMSO:1.5 mg/mL (3.75 mM)
H2O:3 mg/mL (7.50 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years