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Maytansinol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Maytansinol图片
CAS NO:57103-68-1
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
美登醇
Ansamitocin P-0
产品介绍
Maytansinol 在体外抑制微管组装并导致微管分解。它与辐射联用,用于果蝇和人类癌细胞。

产品描述

Maytansinol inhibits microtubule assembly and causes microtubule disassembly in vitro.

体外活性

Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol causes apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to the drug. Maytansinol decreases the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses.

Cas No.

57103-68-1

分子式

C28H37ClN2O8

分子量

565.06

别名

美登醇;Ansamitocin P-0

储存和溶解度

DMSO:35 mg/mL (61.94 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years