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N-glycolyl-Ganglioside GM3 Mixture(ammonium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:69345-49-9
包装:1 mg
市场价:-1元

产品名称
N-glycolyl-Ganglioside GM3 Mixture (ammonium salt)
产品介绍

产品描述

N-glycolyl-Ganglioside GM3(NeuGc-GM3) is a form of ganglioside GM3 that contains an N-glycolylated sialic acid (NeuGc).

体外活性

It is not biosynthesized in humans under baseline conditions due to a mutation in CMP-Neu5Ac hydroxylase (CMAH), which converts N-acetyl sialic acid to N-glycolyl sialic acid, but NeuGc can be taken up by human cellsviathe diet and incorporated into glycolipids, such as ganglioside GM3.1,2NeuGc-GM3 impairs differentiation and maturation of dendritic cellsin vitroand reduces CD4 expression in non-activated T cells.1,3It increases the number of lung tumor nodules formed in a murine Lewis lung carcinoma model.4It is found in a variety of human cancers, including breast and lung cancers, as well as pediatric cancers.1Levels of NeuGc-GM3 are negatively correlated with the number of mature dendritic cells in patient-derived non-small cell lung cancer (NSCLC) tumor tissue.5Anti-NeuGc-GM3 antibodies, able to destroy tumor cells in vitro, have been found in individuals without cancer but not in patients with NSCLC.1,6N-glycolyl-Ganglioside GM3mixture contains ganglioside GM3molecular species with primarily C22:0, C23:0, and C24:0 fatty acyl chain lengths.

Cas No.

69345-49-9

分子式

C64H117N2O22?NH4 (for tricosanoyl)

分子量

1284.7

别名

N-glycolyl-Ganglioside GM3 Mixture (ammonium salt)

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years