Pyrrole-2-carboxylic acid 是一种天然生物碱类，从海洋细菌Pelomonas puraquaesp. Nov 中分离得到。

Pyrrole-2-carboxylic acid was first identified as a degradation product of sialic acids, then as a derivative of the oxidation of the D-hydroxyproline isomers by mammalian D-amino acid oxidase. The latter relationship results from the lability of the direct oxidation product, A'-pyrroline-4-hydroxy-2-carboxylic acid, which loses water spontaneously to form the pyrrole. A similar reaction is catalyzed by the more specific allohydroxy-D-proline oxidase of Pseudomonas. In whole animal observations, pyrrole-2-carboxylate (PCA) ' was identified in rat or human urine after administration of the D-isomers of hydroxyproline, a finding ascribable to the action of D-amino acid oxidase. Urinary excretion of N-(pyrrole-2-carboxyl) glycine has been reported in a 5-year-old affected with type II hyperprolinemia; The child has mild developmental delay, recurrent seizures of the grand mal type and EEG alterations.

634-97-9

C5H5NO2

111.1

Minaline;2-Pyrrolecarboxylic acid;吡咯-2-羧酸

DMSO:10uM
Methanol:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years