MIRA-1 是马来酰亚胺类似物。它可以恢复p53依赖的转录转激活诱导 p53 突变细胞凋亡，具有抗肿瘤作用。

MIRA-1 is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with an IC50 of 20 μM.

MIRA-1 induces p53 transcriptional transactivation of p21, MDM2, and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro with an IC50 of 10μM[1].

72835-26-8

C8H9NO4

183.16

NSC 19630;(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate;p53 Activator VIII;1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione;WRN Helicase Inhibitor

DMSO:20 mg/mL(109.19 mM)
Ethanol:20 mg/mL(109.19 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years