LDN212854 是一种新型BMP抑制剂，抑制 ALK2 的IC50=1.3 nM，比对ALK1，ALK3，ALK4和ALK5的抑制性高2，66，1641和7135倍。

LDN-212854, a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus ALK1/3 compared to other inhibitors.

LDN-212854（6 mg/kg,i.p.）有效地使体内ALK2信号失效,能有效抑制进行性骨化性纤维发育不良的可诱导转基因突变体ALK2小鼠的异位骨化.

在成肌纤维C2C12细胞中,相比BMP6与BMP4诱导的成骨分化,LDN-212854对BMP6的选择性更高。

1432597-26-6

C25H22N6

406.493

LDN212854;BMP Inhibitor III

2eq.HCl:20.3 mg/mL (50 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years