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IHMT-PI3Kδ-372
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IHMT-PI3Kδ-372图片
CAS NO:2429889-62-1
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
IHMT-PI3Kδ-372 是一种选择性的 PI3Kδ 抑制剂,IC50 为 14 nM,可用于慢性阻塞性肺病的研究。

产品描述

IHMT-PI3Kδ-372 is a selective inhibitor of PI3Kδ with an IC50 of 14 nM and can be used in studies about chronic obstructive pulmonary disease.

体外活性

In Raji cells, IHMT-PI3Kδ-372 (0.03-3 μM) inhibits PI3Kδ-mediated AKT T308 phosphorylation (EC50 = 67 nM).IHMT-PI3Kδ-372 moderately inhibits CYP2C9 (IC50 = 2.7 μM) and no apparently inhibits CYP1A2, CYP2B6, CYP2C19, and CYP3A4 (IC50s >10 μM)[1].

体内活性

IHMT-PI3Kδ-372 (1-5 mg/kg; inhalation) improves lung function and reduced the inflammatory patterns characteristic of COPD with better forced expiratory volume in FEV1, FVC, and PEF. IHMT-PI3Kδ-372 dose-dependently decreases the inflammatory cell and reduces the abnormally high level of leukocytes including the alveolar macrophages, neutrophils, and lymphocytes. In rats, IHMT-PI3Kδ-372 (5 mg/kg; inhalation) displays a half-life of 2.3 h, low exposure of 66 ng/mL, and high clearance of 348.5 mL/min/kg in plasma and high exposure of 5599 ng/g (6 h after inhalation) in lung tissue[1].

Cas No.

2429889-62-1

分子式

C26H23F2N7O2

分子量

503.5

别名

IHMT-PI3Kδ-372

储存和溶解度

DMSO:37.8mg/mL (75.1mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years