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LCB 03-0110 dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议

产品介绍
LCB 03-0110 Dihydrochloride是BTK和Syk家族以及DDR2家族中c-Src激酶(IC50=1.3 nM)和酪氨酸激酶的有效抑制剂。在体外抑制LPS诱导的巨噬细胞活化和TGF-β1诱导的成纤维细胞活化,抑制巨噬细胞和成纤维细胞的活化,并抑制伤口愈合模型中的瘢痕形成。

产品描述

LCB 03-0110 Dihydrochloride is a potent inhibitor of the c-Src kinase (IC50 = 1.3 nM) and tyrosine kinases in the BTK and SYK family, as well as in the DDR2 family. It inhibits LPS-induced activation of macrophages and TGF-β1-induced activation of fibroblasts in vitro, inhibits activation of macrophages and fibroblasts, and inhibits scarring in wound healing models.

体外活性

LCB 03-0110 treatment of cells exposed to TGF-β1 and type I collagen showed a marked inhibition preferentially in the phosphorylation of tyrosine 861, to give approximately 50% reduction at 1 μM and an almost complete abolishment at 3 μM.

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years