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ML239
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ML239图片
CAS NO:1378872-36-6
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
CID-49843203
产品介绍
ML239 是乳腺癌肿瘤干细胞的选择性抑制剂(C50:1.16 μM)。

产品描述

ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM.

体外活性

ML239 (Compound 7j) is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM, with ~24-fold selectivity against the control cell line. ML239 inhibits breast cancer stem-like cells, most likely through activation of fatty acid desaturase 2 (FADS2). ML239 is cytotoxic to NCIH661 cells, and FADS2 knockdown reduces ML239 cytotoxicity, and furthermore, FADS2 inhibitor SC-26196 also reduces ML239 cytotoxicity in cancer cell lines (CCLs)

激酶实验

ML239 is dissolved in DMSO.Cancer cell lines (CCLs) are plated at a density of 500 cells/well in white opaque tissue-culture-treated Aurora 1536-well MaKO plates in the provider-recommended growth media using a highly automated platform. Compounds (ML239) are added by acoustic transfer using a Labcyte Echo 555. 24 hours after plating. The effects of small molecules (ML239) are measured over a 16-point concentration range (two-fold dilution) in duplicate. DMSO is used at a constant concentration of 0.33%, including vehicle-only control wells. As a surrogate for viability, cellular ATP levels are assessed 72 hours after compound transfer by addition of CellTiterGlo followed by luminescence measurement using a ViewLux Microplate Imager. Duplicates are averaged and luminescence values normalized to vehicle (DMSO) treatment and background (media-only) wells

Cas No.

1378872-36-6

分子式

C13H10Cl3N3O2

分子量

346.59

别名

CID-49843203

储存和溶解度

Ethanol:50 mM
DMSO:300 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years