Eberconazole nitrate 是一种二氯咪唑衍生物,具有抗真菌活性,效果比Ketoconazole、Clotrimazole和Miconazole强。它通过局部给药对皮肤癣菌病具有潜在的研究价值。
产品描述
Eberconazole Nitrate is an azole antifungal agent and broad-spectrum imidazole derivative.
体内活性
Spherical and porous Eberconazole Nitrate(EB) microsponge particles were obtained.?The optimized microsponges possessed particle size, drug content and entrapment efficiency of 24.5 μm, 43.31% and 91.44%, respectively.?Microsponge-loaded gels demonstrated controlled release, nonirritancy to rat skin and antifungal activity.?An in vivo skin deposition study demonstrated fourfold higher retention in the stratum corneum layer as compared with commercial cream[1].
动物实验
Eberconazole Nitrate(EB) microsponges were prepared using the quasiemulsion solvent diffusion method.?The effect of formulation variables (drug:polymer ratio, internal phase volume and amount of emulsifier) and process variables (stirring time and stirring speed) on the physical characteristics of microsponges were investigated.?The optimized microsponges were dispersed into a hydrogel and evaluated[1].
Cas No.
130104-32-4
分子式
C18H15Cl2N3O3
分子量
392.24
别名
硝酸依柏康唑;Ebernet
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years