C25-140 是一种具有口服活性和一定选择性的TRaf6-Ubc13相互作用抑制剂。它直接与 TRaf6 结合，阻断 TRaf6 和 Ubc13 的相互作用，降低 TRaf6 和NF-Κb的活性，并与自身免疫对抗。

C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.

C25-140 dose-dependently impedes TRAF6-Ubc13 interaction.It?(10-30 μM;?2 hours) effectively reduces TRAF6-mediated ubiquitin chain formation.

Cell Line:TRAF6WT . Concentration:10 μM, 20 μM, 30 μM . Incubation Time:2 hours

1358099-18-9

C26H31N7O

457.582

DMSO:62.5 mg/mL (136.59 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years