Dimethindene是H1受体的选择性拮抗剂，阻断K+电流。Dimethindene表现出抗组胺和抗胆碱作用。

Dimethindene is a selective antagonist of H1 receptor and blocks K+ current. Dimethindene exhibits antihistamine and anticholinergic effects.

In follicle-enclosed Xenopus oocytes, Dimethindene (5-500 μM) decreases Cromakalim cromakalim-induced K+ currents (IC50 = 29.5 μM)[1].

In C57BL/6 mice with skin wound healing, Dimethindene (0.25 mg; i.p.) impairs cutaneous wound healing and delays skin wound closure[2].

5636-83-9

C20H24N2

292.42

Dimetindene;二甲茚定;Dimetindeno

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years