Ceanothic acid derivatives show cytotoxic effect against OVCAR-3 and HeLa cancer cell lines.

Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from Ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo-Ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 microg/mL, respectively, and an IC50 of 11.3 microg/mL against normal cell line FS-5.

21302-79-4

C30H46O5

486.68

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years